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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-(3-Ethyl-sulfanyl-5-phenyl-1-benzofuran-2-yl)acetic acid
Abstract:
The title compound, C(18)H(16)O(3)S, crystallizes with two symmetry-independent mol-ecules in the asymmetric unit. The phenyl rings are rotated out of the benzofuran planes, making dihedral angles of 43.38 (7) and 56.13 (6)° in the two mol-ecules. The carboxyl groups are involved in inversion-related inter-molecular O-H⋯O hydrogen bonds, which link the mol-ecules into centrosymmetric dimers. These dimers are further packed into stacks along the b axis by weak non-classical inter-molecular C-H⋯O hydrogen bonds. The crystal structure also exhibits inter-molecular C-H⋯π inter-actions, and two aromatic π-π inter-actions between the furan rings of neighbouring benzofuran systems; the centroid-centroid distances are 3.500 (3) and 3.605 (3) Å.
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