Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...
Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
Alkyl Halides02:45

Alkyl Halides

Structural Properties
Alkyl halides are halogen-substituted alkanes wherein one or more hydrogen atoms of an alkane is replaced by a halogen atom such as fluorine, chlorine, bromine, or iodine. The carbon atom in an alkyl halide is bonded to the halogen atom, which is sp3-hybridized and exhibits a tetrahedral shape.
Unlike alkyl halides, compounds in which a halogen atom is bonded to an sp2 -hybridized carbon atom of a carbon-carbon double bond (C=C) are called vinyl halides. Whereas aryl...
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substituent-modulated excited-state dynamics and solvent-sensitized nanosecond triplet harvesting in donor-acceptor TADF emitters.

Physical chemistry chemical physics : PCCP·2026
Same author

Interfacial impedance engineering in ionic hydrogels for integrated enzymatic and electrophysiological sensing.

Biosensors & bioelectronics·2026
Same author

Novel 2-Anilinoquinazoline derivatives as apoptosis-inducing agents in drug-resistant NSCLC cells: Integrating biological and computational evaluation.

Bioorganic chemistry·2026
Same author

A new anilinoquinazoline derivative, F307 induces autophagy and differential apoptosis in wild-type and mutated-epidermal growth factor receptor non-small cell lung cancer cell lines.

Anti-cancer drugs·2025
Same author

Overcoming EGFR mutation resistance: Dual inhibition strategies using TKIs in non-small cell lung cancer therapy.

European journal of medicinal chemistry·2025
Same author

Microwave-Assisted Buchwald-Hartwig Double Amination: A Rapid and Promising Approach for the Synthesis of TADF Compounds.

ACS omega·2025

Related Experiment Video

Updated: Jun 1, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

N-(4-Methoxy-phen-yl)phthalimide.

Yoke Ling Sim1, Azhar Ariffin, Mohammad Niyaz Khan

  • 1Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Acta Crystallographica. Section E, Structure Reports Online
|May 18, 2011
PubMed
Summary

This study details the molecular structure of a novel phthalimide compound, C(15)H(11)NO(3). The research reveals a significant dihedral angle between its fused-ring system and phenyl-ene ring, crucial for understanding its chemical properties.

More Related Videos

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)
08:46

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)

Published on: November 22, 2016

Production and Testing of Antimicrobial Peptides and Their Mimics
10:35

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Related Experiment Videos

Last Updated: Jun 1, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)
08:46

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of Phosphorus(I)

Published on: November 22, 2016

Production and Testing of Antimicrobial Peptides and Their Mimics
10:35

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Area of Science:

  • Crystallography
  • Organic Chemistry
  • Materials Science

Background:

  • Phthalimide derivatives are important in medicinal chemistry and materials science.
  • Understanding the three-dimensional structure of organic compounds is key to predicting their properties and reactivity.
  • The specific compound C(15)H(11)NO(3) has potential applications that warrant structural investigation.

Purpose of the Study:

  • To determine the precise crystal structure of the title compound, C(15)H(11)NO(3).
  • To analyze the spatial arrangement and dihedral angles between key ring systems within the molecule.
  • To provide foundational structural data for future research and development of related compounds.

Main Methods:

  • Single-crystal X-ray diffraction was employed to collect diffraction data.
  • The crystal structure was solved and refined using standard crystallographic software.
  • Geometric analysis was performed to measure bond lengths, bond angles, and dihedral angles.

Main Results:

  • The crystal structure of C(15)H(11)NO(3) was successfully elucidated.
  • A significant dihedral angle of 60.0(1)° was measured between the phthalimide fused-ring system and the phenyl-ene ring.
  • The molecular packing and intermolecular interactions in the crystal lattice were also observed.

Conclusions:

  • The determined dihedral angle provides critical insight into the compound's conformation.
  • This structural information is vital for understanding the electronic and physical properties of C(15)H(11)NO(3).
  • The findings lay the groundwork for designing new molecules with tailored properties based on phthalimide scaffolds.