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Updated: Jun 1, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
[3-Bromo-2-(3-fluoro-benz-yloxy)phen-yl]boronic acid
Kinga Kacprzak1, Tomasz Klis, Janusz Serwatowski
1Physical Chemistry Department, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
Abstract:
In the title compound, C(13)H(11)BBrFO(3), the dioxy-boron fragment is close to co-planar with the benzene ring to which the B atom is connected [dihedral angle = 8.96 (4)°]. The dihedral angle between the two benzene rings is 14.8 (2)°. One of the OH groups is engaged in an intra-molecular O-H⋯O hydrogen-bonding inter-action. The second OH group is involved in inter-molecular hydrogen bonding, forming a centrosymmetric dimer. The F atom and the corresponding meta-H atom are disordered over two positions in a 0.675 (6):0.325 (6) ratio.
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