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Updated: Jun 1, 2026
06:46
Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
(1E,4E)-1,5-Bis(2,4-dimethyl-phen-yl)penta-1,4-dien-3-one
Summary
This study details the molecular structure of a curcumin derivative, C(21)H(22)O. The research specifically quantifies the dihedral angle between its aromatic ring planes, revealing a distinct spatial arrangement.
Area of Science:
- Medicinal Chemistry
- Crystallography
- Organic Chemistry
Background:
- Curcumin is a biologically active compound with diverse therapeutic properties.
- Derivatives of curcumin are synthesized to explore enhanced or novel pharmacological activities.
- Understanding the three-dimensional structure of curcumin derivatives is crucial for structure-activity relationship studies.
Purpose of the Study:
- To characterize the crystal structure of a novel curcumin derivative, C(21)H(22)O.
- To determine the precise spatial arrangement of the aromatic ring systems within the C(21)H(22)O molecule.
- To provide foundational structural data for future investigations into the biological activity of this curcumin analog.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular structure.
- The crystal structure was solved and refined using standard crystallographic techniques.
- The dihedral angle between the aromatic ring planes was accurately measured.
Main Results:
- The title compound C(21)H(22)O was successfully synthesized and characterized.
- The crystal structure revealed a specific molecular conformation.
- A dihedral angle of 20.57(11)° was measured between the two aromatic ring planes.
Conclusions:
- The determined dihedral angle provides key insights into the solid-state conformation of this curcumin derivative.
- This structural information is vital for understanding potential intermolecular interactions and biological target binding.
- The findings contribute to the broader knowledge of curcumin analog structural diversity and its implications for drug design.
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