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Related Experiment Video

Updated: Jun 1, 2026

Full-Endoscopic Interlaminar Approach for Decompression of Lateral Recess Stenosis

Full-Endoscopic Interlaminar Approach for Decompression of Lateral Recess Stenosis

Published on: February 24, 2023

(-)-istanbulin a.

Matías López-Rodríguez, Matías Reina, D M Domínguez-Díaz

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This study details a sesquiterpene lactone from Senecio candidans, confirming its structure and stereochemistry using NMR and crystal data. The compound

Area of Science:

Natural Product Chemistry
Organic Chemistry
Plant Chemistry

Background:

Senecio candidans, a plant from the Chilean Magallanes region, is a source of novel chemical compounds.
Sesquiterpene lactones are a class of natural products with diverse biological activities.
Eremophilanolides represent a specific structural subclass of sesquiterpene lactones.

Purpose of the Study:

To confirm the atomic connectivity of a specific sesquiterpene lactone isolated from Senecio candidans.
To elucidate the relative stereochemistry of key chiral centers within the molecule.
To investigate the solid-state structure and intermolecular interactions of the compound.

Main Methods:

Nuclear Magnetic Resonance (NMR) spectroscopy (1H and 13C) was employed for structural elucidation.

Related Experiment Videos

Last Updated: Jun 1, 2026

Full-Endoscopic Interlaminar Approach for Decompression of Lateral Recess Stenosis

Full-Endoscopic Interlaminar Approach for Decompression of Lateral Recess Stenosis

Published on: February 24, 2023

X-ray crystallography was used to determine the crystal structure and confirm relative stereochemistry.

Analysis of intermolecular hydrogen bonding patterns in the crystal lattice.

Main Results:

The atomic connectivity of the title compound, a sesquiterpene lactone, was unequivocally confirmed.
The relative stereochemistry of the 4α-methyl, 5α-methyl, 8β-hydroxy, and 10β-H configuration was established.
Crystal structure analysis revealed stabilization via intermolecular O-H⋯O hydrogen bonds forming chains along the a-axis.

Conclusions:

The structural assignment of the sesquiterpene lactone from Senecio candidans is validated.
The study provides detailed insights into the molecular structure and solid-state organization.
The absolute configuration could not be determined due to the absence of suitable anomalous scatterers.