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Updated: Jun 1, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
{2-[(2,6-Difluoro-phen-oxy)meth-yl]phen-yl}boronic acid
Tomasz Klis1, Janusz Serwatowski
1Physical Chemistry Department, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
Abstract:
The planes of the two benzene rings in the mol-ecule of the title compound, C(13)H(11)BF(2)O(3), form a dihedral angle of 76.06 (3)°; the C-O-C-C torsion angle characterizing the conformation of the central link of the mol-ecule is -79.20 (1)°. The dihydroxy-boron group is not coplanar with the benzene ring bonded to the B atom; one of the C-C-B-O torsion angles is 32.39 (2)°. One of the OH groups of the boronic acid fragment is engaged in an intra-molecular hydrogen bond, whereas the second OH group participates in inter-molecular hydrogen bonding, which leads to the formation of centrosymmetric dimers.
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