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Updated: Jun 1, 2026
11:04
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
(2E)-2-Hydroxy-imino-N'-[(E)-2-pyridyl-methyl-ene]propanohydrazide
Summary
This study details the crystal structure of a pyridine compound, C(9)H(10)N(4)O(2). Molecular analysis reveals twisted pyridine rings, intramolecular hydrogen bonds, and layered crystal packing through intermolecular interactions.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Understanding the three-dimensional arrangement of atoms in organic molecules is crucial for predicting their properties and reactivity.
- Pyridine derivatives are important scaffolds in medicinal chemistry and materials science.
Purpose of the Study:
- To elucidate the detailed crystal structure of the compound C(9)H(10)N(4)O(2).
- To investigate the intermolecular interactions and crystal packing of the pyridine derivative.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and non-bonded contacts provided insights into molecular geometry and interactions.
Main Results:
- The pyridine ring in C(9)H(10)N(4)O(2) exhibits a significant twist of 16.5(1)° relative to the plane of the other non-hydrogen atoms.
- Intramolecular N-H⋯N hydrogen bonding was identified within the molecule.
- Intermolecular hydrogen bonds (O-H⋯N and N-H⋯O) organize molecules into layers parallel to the bc plane.
- π-π stacking interactions between pyridine rings were observed, with a centroid-to-centroid distance of 3.649(1) Å.
Conclusions:
- The crystal structure of C(9)H(10)N(4)O(2) is characterized by a non-planar pyridine ring and extensive intermolecular hydrogen bonding.
- These interactions lead to a layered supramolecular architecture stabilized by π-π stacking, influencing the solid-state properties.
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