Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NMR Spectroscopy of Benzene Derivatives01:37

NMR Spectroscopy of Benzene Derivatives

Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling constants depend...
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Substituent Position in Coumarin Derivatives during their Interaction with TiO<sub>2</sub> Nano Particles.

Journal of fluorescence·2021
Same author

A click chemistry approach for the synthesis of cyclic ureido tethered coumarinyl and 1-aza coumarinyl 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis H37Rv and their in silico studies.

Bioorganic & medicinal chemistry·2019
Same author

Crystal structure of 4-(4b,8a-di-hydro-9<i>H</i>-pyrido[3,4-<i>b</i>]indol-1-yl)-7-methyl-2<i>H</i>-chromen-2-one.

Acta crystallographica. Section E, Crystallographic communications·2017
Same author

One pot Click chemistry: A three component reaction for the synthesis of 2-mercaptobenzimidazole linked coumarinyl triazoles as anti-tubercular agents.

Bioorganic & medicinal chemistry letters·2016
Same author

Rhodium-Catalyzed Regioselective Synthesis of Isocoumarins through Benzothiadiazine-Fused Frameworks.

Organic letters·2016
Same author

Crystal structure of 2-(5-meth-oxy-1-benzo-furan-3-yl)acetic acid.

Acta crystallographica. Section E, Crystallographic communications·2016

Related Experiment Video

Updated: Jun 1, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

4-Bromo-methyl-7-methyl-6,8-dinitro-coumarin.

Ramakrishna Gowda, Ganesh N Alawandi, Manohar V Kulkarni

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    The crystal structure of a nitrated coumarin derivative was determined. This study clarifies the positions of nitro groups added during the chemical reaction, providing insights into the molecule's geometry.

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Chemical Synthesis

    Background:

    • Coumarin derivatives are important scaffolds in medicinal chemistry and materials science.
    • Nitration reactions are common methods for functionalizing aromatic systems.
    • Understanding the precise structure of synthesized compounds is crucial for further research.

    Purpose of the Study:

    • To determine the crystal structure of the nitrated derivative of 7-methyl-4-bromocoumarin.
    • To confirm the regioselectivity of the nitration reaction on the coumarin core.
    • To analyze the spatial arrangement of the nitro groups relative to the coumarin ring system.

    Main Methods:

    • Single-crystal X-ray diffraction analysis was employed to elucidate the molecular structure.

    More Related Videos

    Elucidating the Metabolism of 2,4-Dibromophenol in Plants
    06:54

    Elucidating the Metabolism of 2,4-Dibromophenol in Plants

    Published on: February 10, 2023

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
    14:22

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

    Published on: April 15, 2013

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
    09:56

    Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

    Published on: November 18, 2015

    Elucidating the Metabolism of 2,4-Dibromophenol in Plants
    06:54

    Elucidating the Metabolism of 2,4-Dibromophenol in Plants

    Published on: February 10, 2023

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
    14:22

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

    Published on: April 15, 2013

  • The crystal structure was solved and refined to atomic resolution.
  • Geometric parameters, including bond lengths, bond angles, and dihedral angles, were analyzed.

    • Main Results:

    • The crystal structure of C(11)H(7)BrN(2)O(6) was successfully established.
    • The substitution positions of the two nitro groups were unequivocally identified.
    • The nitro groups were found to be oriented at specific dihedral angles (43.9(8)° and 52.7(10)°) relative to the planar benzopyran ring.

    Conclusions:

    • The nitration of 7-methyl-4-bromocoumarin yields a product with nitro groups at specific positions.
    • The crystal structure provides definitive evidence for the reaction's outcome.
    • The determined molecular geometry is essential for understanding the compound's properties and reactivity.