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Related Concept Videos

Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme activation, sulfur...
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Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides01:16

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Naming Acid Halides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...
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Carboxylic Acid Derivatives: Overview

Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

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Published on: May 27, 2014

2-methanesulfonamidobenzoic Acid.

Muhammad Shafiq, Muhammad Zia-Ur-Rehman, Islam Ullah Khan

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study details the crystal structure of a novel compound, C(8)H(9)NO(4)S. Molecular analysis reveals intra-molecular hydrogen bonds forming a six-membered ring and intermolecular hydrogen bonds creating dimers.

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    Area of Science:

    • Crystallography
    • Molecular Chemistry
    • Supramolecular Chemistry

    Background:

    • Understanding molecular interactions is crucial in chemistry.
    • Hydrogen bonds play a significant role in molecular assembly and material properties.
    • The specific compound C(8)H(9)NO(4)S was synthesized for structural investigation.

    Purpose of the Study:

    • To elucidate the crystal structure of the compound C(8)H(9)NO(4)S.
    • To identify and characterize intra- and intermolecular hydrogen bonding networks.
    • To understand the self-assembly behavior of the molecule in the solid state.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the three-dimensional structure.
    • Analysis of bond lengths, bond angles, and intermolecular contacts.
    • Hydrogen bond geometry was analyzed to understand their strength and directionality.

    Main Results:

    • The crystal structure of C(8)H(9)NO(4)S was successfully determined.
    • An intra-molecular N-H⋯O hydrogen bond was observed, forming a stable six-membered ring.
    • Intermolecular O-H⋯O and C-H⋯O hydrogen bonds link molecules into centrosymmetric dimers and extended networks.

    Conclusions:

    • The compound C(8)H(9)NO(4)S exhibits specific intra- and intermolecular hydrogen bonding patterns.
    • These hydrogen bonds dictate the formation of dimers and influence the overall crystal packing.
    • The findings contribute to the understanding of structure-property relationships in organic compounds.