(E)-2-(Isonicotinoylhydrazonometh-yl)benzoic acid methanol monosolvate

Area of Science:

• Organic Chemistry
• Crystallography
• Supramolecular Chemistry

Background:

• Hydrazone derivatives are known for diverse biological activities.
• Understanding the structural features of novel compounds is crucial for further applications.
• The synthesis and characterization of new organic molecules contribute to chemical knowledge.

Purpose of the Study:

• To synthesize a new hydrazone compound derived from isonicotinohydrazide and 2-formyl-benzoic acid.
• To elucidate the crystal structure and molecular geometry of the synthesized compound.
• To investigate the intermolecular interactions, specifically hydrogen bonding, within the crystal lattice.

Main Methods:

• Condensation reaction between isonicotinohydrazide and 2-formyl-benzoic acid in methanol.
• Single crystal X-ray diffraction to determine the crystal structure.
• Analysis of bond configurations, dihedral angles, and hydrogen bonding patterns.

Main Results:

• Successful synthesis of the title compound, C(14)H(11)N(3)O(3)·CH(4)O.
• The hydrazone molecule exhibits an E configuration around the C=N bond.
• A small dihedral angle (12.04°) between the pyridine and benzene rings was observed.
• Extensive O-H⋯N, O-H⋯O, and N-H⋯O hydrogen bonds were identified, forming a crystal network.

Conclusions:

• The synthesized hydrazone possesses a defined molecular structure with specific ring orientations.
• Hydrogen bonding plays a significant role in the self-assembly and stabilization of the crystal structure.
• This structural characterization provides a foundation for exploring the potential applications of this novel hydrazone.