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Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2-(2-Chloro-3-quinol-yl)-3-phenyl-thia-zolidin-4-one
Abstract:
In the title compound, C(18)H(13)ClN(2)OS, the thia-zolidinone ring is slightly distorted and adopts a envelope conformation. The basal plane is nearly perpendicular to the quinoline ring, forming a dihedral angle of 86.1 (1)°, and makes a dihedral angle of 14.9 (1)° to the benzene ring. The benzene ring is also nearly perpendicular to the quinoline ring, forming a dihedral angle of 89.4 (1)°. In the crystal, non-classical C-H⋯O and C-H⋯N hydrogen bonds link the mol-ecules, forming polymers along b.
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