Related Experiment Video
Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2,2'-o-Phenyl-enediacetonitrile.
Yang Li1, Guoxiong Hua, Alexandra M Z Slawin
1Department of Chemistry, University of St Andrews, St Andrews KY16 9ST, Scotland.
This study analyzes the crystal structure of NCCH(2)C(6)H(4)CH(2)CN, revealing normal bond parameters. Weak C-H⋯N hydrogen bonds stabilize the structure through anti-parallel chains and ring systems.
Area of Science:
- Crystallography
- Supramolecular Chemistry
- Organic Chemistry
Background:
- Understanding the intermolecular forces governing crystal packing is crucial in materials science.
- Non-conventional hydrogen bonds play a significant role in stabilizing crystal lattices.
Purpose of the Study:
- To characterize the crystal structure of the organic compound NCCH(2)C(6)H(4)CH(2)CN.
- To investigate the role of weak hydrogen bonding in the compound's crystal stabilization.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular geometry and crystal packing.
- Analysis of bond lengths, bond angles, and dihedral angles provided insights into molecular conformation.
Main Results:
- The compound exhibits normal bond lengths and angles, indicating a stable molecular structure.
- Dihedral angles between the benzene ring and C-C-C-N planes were measured at 4.94(8)° and 77.04(8)°.
- Weak non-conventional C-H⋯N hydrogen bonds were identified as key stabilizing interactions, forming anti-parallel chains and ring systems.
Conclusions:
- The crystal structure of NCCH(2)C(6)H(4)CH(2)CN is primarily stabilized by weak C-H⋯N hydrogen bonds.
- These interactions lead to the formation of specific supramolecular architectures, including anti-parallel chains and ring systems.
More Related Videos
06:46Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
10:42Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Related Concept Videos
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
Nitrosation of Enols
2° Amines to N-Nitrosamines: Reaction with NaNO2
Structures of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...