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Published on: May 15, 2019
2-Hydr-oxy-1-methoxyxanthen-9-one monohydrate
Guangying Chen1, Jun Zhao, Changchun Cen
1Hainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China.
Summary
This study details a xanthene compound isolated from Calophyllum membranaceum roots. Its crystal structure reveals an almost planar ring system stabilized by intermolecular hydrogen bonds.
Area of Science:
- Natural Product Chemistry
- Crystallography
- Organic Chemistry
Background:
- Calophyllum membranaceum is a plant species known for its diverse phytochemical constituents.
- Xanthene derivatives are recognized for their potential biological activities.
- Understanding the structural properties of isolated compounds is crucial for further research.
Purpose of the Study:
- To isolate and characterize a novel compound from the roots of Calophyllum membranaceum.
- To elucidate the crystal structure of the isolated xanthene derivative.
- To investigate the intermolecular interactions within the crystal lattice.
Main Methods:
- Compound isolation using chromatographic techniques.
- Single crystal X-ray diffraction analysis to determine molecular and crystal structure.
- Analysis of bond lengths, bond angles, and intermolecular interactions.
Main Results:
- Isolation of a xanthene compound with the chemical formula C(14)H(10)O(4)·H(2)O.
- The xanthene ring system exhibits a near-planar conformation with a root-mean-square deviation of 0.008 Å.
- Intermolecular hydrogen bonds (O-H⋯O and O-H⋯(O,O)) were identified, linking the molecules in the crystal structure.
Conclusions:
- The structural characterization of the isolated xanthene compound provides fundamental data for its identification.
- The observed planarity of the xanthene core may influence its chemical reactivity and biological interactions.
- The hydrogen bonding network plays a significant role in the supramolecular assembly of the compound in the solid state.
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