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Related Concept Videos

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
Structure and Nomenclature of Thiols and Sulfides02:17

Structure and Nomenclature of Thiols and Sulfides

Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry, similar...
Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
Electrophilic Aromatic Substitution: Nitration of Benzene01:20

Electrophilic Aromatic Substitution: Nitration of Benzene

The nitration of benzene is an example of an electrophilic aromatic substitution reaction. It involves the formation of a very powerful electrophile, the nitronium ion, which is linear in shape. The reaction occurs through the interaction of two strong acids, sulfuric and nitric acid.
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.

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Related Experiment Video

Updated: Jun 1, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

1,2-Bis(2-nitro-phen-yl)disulfane.

Mingzhi Song, Chuangang Fan

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    The crystal structure of C(12)H(8)N(2)O(4)S(2) reveals a significant dihedral angle between its benzene rings. Molecules are linked by weak intermolecular C-H⋯O hydrogen bonds in the crystal lattice.

    Area of Science:

    • Crystallography
    • Molecular structure analysis
    • Supramolecular chemistry

    Background:

    • Understanding molecular interactions and conformations is crucial in chemical research.
    • Crystal engineering relies on identifying and utilizing intermolecular forces.

    Purpose of the Study:

    • To elucidate the crystal structure and intermolecular interactions of the title compound, C(12)H(8)N(2)O(4)S(2).

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
    • Analysis of the crystal packing to identify non-covalent interactions.

    Main Results:

    • The dihedral angle between the two benzene rings in the title compound was determined to be 67.82(9)°.

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    Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
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    Last Updated: Jun 1, 2026

    Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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    Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

    Published on: April 9, 2018

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

    Published on: April 27, 2017

    Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
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    Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

    Published on: August 20, 2018

  • Weak intermolecular C-H⋯O hydrogen bonds were identified as the primary linking forces between molecules in the crystal.

    • Conclusions:

    • The study provides detailed structural information on C(12)H(8)N(2)O(4)S(2).
    • The identified hydrogen bonding network influences the overall crystal packing and stability.