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Related Concept Videos

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview01:26

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview

Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
Nitrosation of Enols01:19

Nitrosation of Enols

The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.

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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

2-Carb-oxy-1-phenyl-ethanaminium nitrate.

Wen-Xian Liang1, Xiao-Wei Chu, Zhi-Rong Qu

  • 1Ordered Matter Science Research Center, College of Chemistry and Chemical, Engineering, Southeast University, Nanjing 210096, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|May 18, 2011
PubMed
Summary
This summary is machine-generated.

This study details the crystal structure of a nitrate salt, revealing how hydrogen bonds link its components. These interactions form a stable two-dimensional network, crucial for understanding molecular assembly.

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Area of Science:

  • Crystal Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Understanding the intermolecular forces governing crystal structures is fundamental in chemistry.
  • Nitrate salts are common and exhibit diverse packing motifs.
  • Hydrogen bonding plays a critical role in the self-assembly of crystalline materials.

Purpose of the Study:

  • To elucidate the crystal structure and hydrogen bonding interactions of the title nitrate salt (C(9)H(12)NO(2) (+)·NO(3) (-)).
  • To analyze the specific hydrogen bond types and their contribution to crystal packing.
  • To characterize the resulting supramolecular architecture.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
  • Analysis of hydrogen bonding networks, including bifurcated interactions.
  • Identification of intermolecular contacts (N-H⋯O, O-H⋯O, C-H⋯O).

Main Results:

  • The crystal structure reveals a salt composed of a cation (C(9)H(12)NO(2) (+)) and an anion (NO(3) (-)).
  • A bifurcated N-H⋯(O,O) hydrogen bond was observed between the cation and anion.
  • Intermolecular hydrogen bonds (N-H⋯O, O-H⋯O, C-H⋯O) stabilize the crystal lattice.
  • A two-dimensional network structure was formed by the interconnected cations and anions.

Conclusions:

  • The crystal packing of the title nitrate salt is predominantly governed by a network of intermolecular hydrogen bonds.
  • The observed hydrogen bonding pattern results in a stable two-dimensional supramolecular architecture.
  • This detailed structural analysis provides insights into the solid-state behavior of this class of compounds.