Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From triangles to squares - chiral, overcrowded polyimine macrocycles of significant chiroptical response enable the capture of chlorinated solvents.

Scientific reports·2026
Same author

Facile Synthesis of <i>N</i>-vinylindoles via Knoevenagel Condensation: Molecular Features and Biological Activities.

International journal of molecular sciences·2025
Same author

Synthesis, Structure, and Stability of Copper(II) Complexes Containing Imidazoline-Phthalazine Ligands with Potential Anticancer Activity.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Thio-modified trianglimines, a novel group of chiral macrocyclic compounds of high structural dynamics.

Scientific reports·2025
Same author

Modular Synthesis of New Metalloid-Substituted Olefins from Diboryl(Silyl)Ethenes via Suzuki-Miyaura Reactions.

International journal of molecular sciences·2024
Same author

Synthesis and Structure of Novel Hybrid Compounds Containing Phthalazin-1(2<i>H</i>)-imine and 4,5-Dihydro-1<i>H</i>-imidazole Cores and Their Sulfonyl Derivatives with Potential Biological Activities.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Jun 1, 2026

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
12:07

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes

Published on: April 1, 2013

5-Amino-1-naphthol.

Agnieszka Czapik1, Arkadiusz Nitka, Maria Gdaniec

  • 1Faculty of Chemistry, Adam Mickiewicz University, 60-780 Poznań, Poland.

Acta Crystallographica. Section E, Structure Reports Online
|May 18, 2011
PubMed
Summary

This study reveals that molecules of C(10)H(9)NO form a 2D polymer through hydrogen bonds. These molecules also exhibit pi-pi stacking interactions, creating slipped stacks within the crystal structure.

Area of Science:

  • Crystal Engineering
  • Supramolecular Chemistry
  • Organic Chemistry

Background:

  • Hydrogen bonding plays a crucial role in the self-assembly of molecules.
  • Understanding intermolecular interactions is key to designing novel materials.
  • The crystal structure of organic compounds dictates their physical and chemical properties.

Purpose of the Study:

  • To elucidate the crystal structure and intermolecular interactions of the title compound, C(10)H(9)NO.
  • To investigate the role of amino and hydroxyl groups in hydrogen bonding and molecular assembly.
  • To analyze the presence and significance of pi-pi stacking interactions in the crystal lattice.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.

More Related Videos

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
07:11

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity

Published on: September 19, 2025

Related Experiment Videos

Last Updated: Jun 1, 2026

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
12:07

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes

Published on: April 1, 2013

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
07:11

Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity

Published on: September 19, 2025

  • Analysis of hydrogen bonding networks (N-H···O) to understand molecular connectivity.
  • Investigation of pi-pi stacking interactions between aromatic rings.

    • Main Results:

    • The compound C(10)H(9)NO forms a two-dimensional polymeric structure driven by intermolecular hydrogen bonds (N-H···O).
    • Molecules are arranged in slipped stacks facilitated by pi-pi stacking interactions with an inter-planar distance of 3.450(4) Å.
    • The amino nitrogen atom exhibits sp(3) hybridization, with its hydrogen atoms positioned on the same side of the aromatic ring.

    Conclusions:

    • The study successfully characterized the supramolecular architecture of C(10)H(9)NO, highlighting the interplay of hydrogen bonding and pi-pi stacking.
    • The observed 2D polymeric structure provides insights into crystal engineering strategies for organic molecules.
    • The findings contribute to the understanding of structure-property relationships in crystalline organic materials.