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Facile Preparation of 4-Substituted Quinazoline Derivatives
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Published on: February 15, 2016

4-[(2,5-Dimethyl-anilino)acet-yl]-3,4-di-hydro-quinoxalin-2(1H)-one

Waqar Nasir, Munawar Ali Munawar, Saeed Ahmad

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed

    Abstract:

    In the title compound, C(18)H(19)N(3)O(2), the dihedral angle between the benzene rings is 20.47 (10)° and an intra-molecular N-H⋯O hydrogen bond occurs, generating an S(5) ring. In the crystal, inversion dimers linked by pairs of N-H⋯O hydrogen bonds lead to R(2) (2)(8) loops.

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    Oxidation of Phenols to Quinones01:17

    Oxidation of Phenols to Quinones

    In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
    o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...

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