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Related Concept Videos

Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
Amines to Sulfonamides: The Hinsberg Test01:23

Amines to Sulfonamides: The Hinsberg Test

The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
Nomenclature of Aromatic Compounds with a Single Substituent01:23

Nomenclature of Aromatic Compounds with a Single Substituent

Benzene is the simplest aromatic hydrocarbon or arene. The IUPAC names for simple monosubstituted benzene derivatives are derived by adding the substituent's name as a prefix to the parent benzene. For example, halobenzene, where the halogen could be fluoro (F), chloro (Cl), bromo (Br), and iodo (I).
Nucleophilic Aromatic Substitution: Elimination–Addition01:11

Nucleophilic Aromatic Substitution: Elimination–Addition

Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is confirmed through isotopic...
Electrophilic Aromatic Substitution: Nitration of Benzene01:20

Electrophilic Aromatic Substitution: Nitration of Benzene

The nitration of benzene is an example of an electrophilic aromatic substitution reaction. It involves the formation of a very powerful electrophile, the nitronium ion, which is linear in shape. The reaction occurs through the interaction of two strong acids, sulfuric and nitric acid.

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Related Experiment Video

Updated: Jun 1, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

N-(4-Hydroxy-phen-yl)benzene-sulfon-amide.

Islam Ullah Khan, Irfana Mariam, Muhammad Zia-Ur-Rehman

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    A novel sulfur-containing compound, synthesized from benzene sulfonyl chloride and para-amino-phenol, shows potential as a precursor for biologically active heterocyclic molecules. Its structure is stabilized by specific hydrogen bonding interactions.

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    Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
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    Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

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    In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
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    Area of Science:

    • Organic Chemistry
    • Medicinal Chemistry
    • Crystallography

    Background:

    • Sulfur-containing heterocyclic compounds are crucial in medicinal chemistry.
    • Developing novel precursors is key to synthesizing new biologically active molecules.
    • Understanding structural stabilization is important for chemical synthesis.

    Purpose of the Study:

    • To synthesize a novel compound with the molecular formula C(12)H(11)NO(3)S.
    • To investigate the potential of this compound as a precursor for bioactive heterocycles.
    • To elucidate the structural features, including hydrogen bonding, of the synthesized compound.

    Main Methods:

    • Chemical synthesis involving the reaction of benzene sulfonyl chloride with para-amino-phenol.
    • Structural characterization of the synthesized compound.
    • Analysis of hydrogen bonding patterns (N-H⋯O and O-H⋯O).

    Main Results:

    • Successful synthesis of the title compound C(12)H(11)NO(3)S.
    • Identification of N-H⋯O and O-H⋯O hydrogen bonds contributing to structural stability.
    • The compound is confirmed as a viable precursor for sulfur-containing heterocyclic synthesis.

    Conclusions:

    • The synthesized compound represents a valuable building block for medicinal chemistry.
    • The identified hydrogen bonding network provides insight into its structural integrity.
    • Further exploration of its derivatives may lead to new therapeutic agents.