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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N'-Acetyl-5-amino-1-methyl-1H-pyrazole-4-carbohydrazonamide dihydrate
Abstract:
In the title compound, C(7)H(12)N(6)O·2H(2)O, the Z configuration of the hydrazone fragment is stabilized by an intra-molecular N-H⋯N hydrogen bond involving one of the amino groups. In the crystal structure, the hydrazonamide mol-ecules are connected via inter-molecular N-H⋯O=C hydrogen bonds, forming C(7) chains running along [010]. The chains form sheets parallel to the (01). The chains are cross-linked by water mol-ecules to form a three-dimensional hydrogen-bonded network.
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Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
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