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Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics

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6-De-oxy-6-fluoro-d-galactose.

Sarah F Jenkinson, Daniel Best, Ken Izumori

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This study confirms the stereochemistry of a novel compound using crystal structure analysis. The molecule forms a hydrogen-bonded network, revealing its three-dimensional structure.

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Area of Science:

Organic Chemistry
Crystallography
Structural Chemistry

Background:

Stereochemistry is crucial for understanding molecular function.
Determining the precise 3D arrangement of atoms in novel compounds is essential.
Hydrogen bonding plays a significant role in molecular assembly and properties.

Purpose of the Study:

To confirm the relative stereochemistry of the C(6)H(11)FO(5) compound.
To elucidate the absolute stereochemistry of the compound.
To investigate the intermolecular interactions and solid-state structure.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the crystal structure.
The synthesis utilized d-galactose as a chiral starting material to establish absolute stereochemistry.
Analysis of the crystal structure revealed the hydrogen bonding network.

Main Results:

The crystal structure unequivocally confirmed the relative stereochemistry of C(6)H(11)FO(5).
The absolute stereochemistry was successfully assigned based on the use of d-galactose.
The compound forms an extensive three-dimensional hydrogen-bonded network.

Conclusions:

The crystal structure provides definitive proof of the compound's stereochemistry.
The identified hydrogen bonding network influences the compound's solid-state packing and properties.
This work contributes to the understanding of fluorinated carbohydrate derivatives.