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Updated: Jun 1, 2026
12:06
Synthesis of High Purity Nonsymmetric Dialkylphosphinic Acid Extractants
Published on: October 19, 2017
Amiloride hydro-chloride methanol disolvate
Summary
This study details the crystal structure of a guanidinium chloride methanol disolvate. The compound forms a complex three-dimensional network through various hydrogen bonds, revealing its intricate molecular arrangement.
Area of Science:
- Crystallography
- Chemical Physics
Background:
- Understanding the crystal structure of organic compounds is crucial for predicting their physical and chemical properties.
- Guanidinium salts and their solvates are of interest due to their diverse applications and complex hydrogen bonding patterns.
Purpose of the Study:
- To elucidate the crystal structure of 2-(3,5-diamino-6-chloro-pyrazin-2-ylcarbon-yl)guanidinium chloride methanol disolvate.
- To characterize the hydrogen bonding network within the crystal.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- The crystal structure was solved and refined.
Main Results:
- The crystal structure reveals a three-dimensional network formed by N-H⋯N, N-H⋯Cl, N-H⋯O, O-H⋯Cl, and O-H⋯O hydrogen bonds.
- The dihedral angle between the aromatic pyrazine ring and the guanidine residue was determined to be 6.0(2)°.
Conclusions:
- The hydrogen bonding interactions dictate the overall three-dimensional architecture of the crystal.
- The structural data provides fundamental insights into the solid-state behavior of this guanidinium derivative.
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