Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nomenclature of Primary Amines01:17

Nomenclature of Primary Amines

Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
Nomenclature of Alkynes02:39

Nomenclature of Alkynes

Alkynes are unsaturated hydrocarbons characterized by the presence of carbon-carbon triple bonds and have a general formula CnH2n-2. The nomenclature of alkynes follows a set of rules similar to alkanes and alkenes; however, alkynes bear the suffix "-yne" instead of "-ane" or "-ene." There are two approaches to naming alkynes:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progression of multiple long-term conditions (multimorbidity) in England: a population-based descriptive study of 49·6 million adults.

The Lancet. Public health·2026
Same author

Waste Biomass Derived Nitrogen-doped Carbon Dots As Efficient Sensors of Environmental Pollutants.

Journal of fluorescence·2025
Same author

Hierarchical Self-Assembly and Aggregation-Induced Emission Enhancement in Tetrabenzofluorene-Based Red Emitting Molecules.

Chemistry, an Asian journal·2024
Same author

Incorporating silver nanoparticles into electrospun nanofibers of casein/polyvinyl alcohol to develop scaffolds for tissue engineering.

International journal of biological macromolecules·2024
Same author

Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases.

Bioorganic chemistry·2024
Same author

Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment.

European journal of medicinal chemistry·2023

Related Experiment Video

Updated: Jun 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

(NE,NE)-N,N-Bis(4-hex-yloxy-3-methoxy-benzyl-idene)ethane-1,2-diamine.

Anju Paul, Sherin Susan Punnoose, N L Mary

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    Researchers synthesized a novel compound, C(30)H(44)N(2)O(4), through the dimerization of 4-hexyl-oxyvanillin and ethylenediamine. This molecule exhibits a trans configuration and a center of symmetry, confirmed by crystallographic analysis.

    More Related Videos

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
    09:45

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

    Published on: April 27, 2017

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
    04:38

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

    Published on: July 28, 2022

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
    09:34

    Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

    Published on: February 6, 2020

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
    09:45

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

    Published on: April 27, 2017

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
    04:38

    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

    Published on: July 28, 2022

    Area of Science:

    • Organic Chemistry
    • Crystallography
    • Supramolecular Chemistry

    Background:

    • Vanillin derivatives are valuable building blocks in organic synthesis.
    • Ethylenediamine is a common diamine linker used in coordination and supramolecular chemistry.
    • Dimerization reactions offer efficient routes to complex molecular architectures.

    Purpose of the Study:

    • To synthesize and characterize a novel dimeric compound derived from 4-hexyl-oxyvanillin and ethylenediamine.
    • To elucidate the structural properties, including stereochemistry and symmetry, of the synthesized molecule.
    • To explore the potential applications of such dimeric structures in materials science or medicinal chemistry.

    Main Methods:

    • Chemical synthesis involving the reaction of 4-hexyl-oxyvanillin with ethylenediamine in a methanol solvent.
    • Purification of the title compound using standard laboratory techniques.
    • Single-crystal X-ray diffraction analysis to determine the molecular structure, configuration, and symmetry.

    Main Results:

    • Successful synthesis of the target compound with the molecular formula C(30)H(44)N(2)O(4).
    • Confirmation of a trans configuration around the C=N imine bond.
    • Determination of a crystallographically imposed center of symmetry within the molecular structure.

    Conclusions:

    • The dimerization of 4-hexyl-oxyvanillin with ethylenediamine provides a straightforward method for generating novel dimeric compounds.
    • The synthesized molecule possesses specific stereochemical and symmetry properties dictated by its crystal packing.
    • Further investigations into the properties and applications of this class of compounds are warranted.