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Related Experiment Video

Updated: Jun 1, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

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Published on: August 22, 2018

1-Acetyl-t-3-ethyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one.

K Ravichandran, S Ponnuswamy, R Rajesh

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This study details the molecular structure of a novel compound, C(23)H(27)NO(4). The research highlights the piperidine ring

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Published on: June 21, 2017

Area of Science:

Chemical Crystallography
Organic Chemistry
Molecular Structure Analysis

Background:

Understanding the three-dimensional arrangement of atoms in organic molecules is crucial for predicting their properties and reactivity.
Piperidine derivatives are prevalent in pharmaceuticals and natural products, necessitating detailed structural characterization.

Purpose of the Study:

To elucidate the precise three-dimensional structure of the title compound, C(23)H(27)NO(4).
To analyze the conformational preferences of the piperidine ring and the orientation of its substituents.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the molecular structure.
Crystallographic data were analyzed to ascertain bond lengths, bond angles, and conformational parameters.

Main Results:

The piperidine ring in C(23)H(27)NO(4) was found to adopt a distorted boat conformation.
Methoxy groups exhibited planarity with their attached benzene rings (maximum deviations of 0.014(3) and 0.007(3) Å).
Benzene rings were oriented at 67.2(1)° and 87.0(1)° relative to the piperidine ring's co-planar atoms.

Conclusions:

The study provides a detailed structural analysis of C(23)H(27)NO(4), revealing a non-planar piperidine core.
The observed conformation and substituent orientations offer insights into the stereochemistry of this organic compound.