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Updated: Jun 1, 2026
Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
(1R,3S,5R,6S)-6-Hydr-oxy-3-tosyl-oxy-tropan-8-ium chloride
Nian-Xi Yu1, Li-Min Yang, Yang Lu
1Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, South Chongqing Road 280, Shanghai 200025, People's Republic of China.
Abstract:
The title compound, C(15)H(22)NO(4)S(+)·Cl(-), is a hydrolysis product of lesatropane [(1R,3S,5R,6S)-6-acet-oxy-3-tosyl-oxytropane] hydro-chloride, a potential anti-glaucoma agent. As in lesatropane, the piperidine and pyrrolidine rings in the title compound adopt chair and envelope conformations, respectively. There are two mol-ecules in the unit cell with similar conformations. The crystal structure is stabilized by inter-molecular O-H⋯Cl and N-H⋯Cl hydrogen bonds.
