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Updated: Jun 1, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 2-(p-toluene-sulfonamido)benzoate
Summary
Researchers synthesized a novel compound, C(15)H(15)NO(4)S, via condensation. Its molecular structure features a significant dihedral angle and is stabilized by intramolecular hydrogen bonding.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure Analysis
Background:
- The synthesis of novel organic compounds is crucial for advancing materials science and medicinal chemistry.
- Understanding molecular geometry and intermolecular interactions provides insights into chemical properties and reactivity.
Purpose of the Study:
- To synthesize and characterize a new organic compound with the molecular formula C(15)H(15)NO(4)S.
- To elucidate the molecular structure, including dihedral angles and hydrogen bonding interactions.
Main Methods:
- Simple condensation reaction between methyl 2-amino-benzoate and 4-methyl-benzene-sulfonyl chloride.
- X-ray crystallography to determine the precise three-dimensional molecular structure.
Main Results:
- Successful synthesis of the target compound C(15)H(15)NO(4)S.
- Determination of a dihedral angle of 84.36° between the two benzene rings.
- Identification of an intramolecular N-H⋯O hydrogen bond stabilizing the molecule, forming an S(6) graph-set motif.
Conclusions:
- The synthesized compound exhibits a specific molecular conformation stabilized by intramolecular hydrogen bonding.
- The structural data provides a foundation for further investigations into the compound's properties and potential applications.
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