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Updated: Jun 1, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
(3R,8aS)-3-Ethyl-perhydro-pyrrolo[1,2-a]pyrazine-1,4-dione
Adailton J Bortoluzzi1, Luciana B P Souza, Antonio C Joussef
1Depto. de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
Abstract:
In the title compound, C(9)H(14)N(2)O(2), the pyrrolidine and piperazine rings adopt envelope and boat conformations, respectively. The chiral centers were assigned on the basis of the known stereogenic center of an enanti-omerically pure starting material and the trans relationship between the H atoms attached to these centers. The crystal packing is stabilized by an inter-molecular hydrogen bond between the N-H group and a carbonyl O atom of the diketopiperazine group, forming zigzag C(5) chains along [010].
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