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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
tert-Butyl 2-(4-chloro-benzo-yl)-2-methyl-propanoate
Chelsey M Crosse1, Emily C Kelly, Marshall W Logue
1Department of Chemistry, 1400 Townsend Drive, Michigan Technological University, Houghton, MI 49931, USA.
Abstract:
The title compound, C(15)H(19)ClO(3), is bent with a dihedral angle of 72.02 (9)° between the mean planes of the benzene ring and a group encompassing the ester functionality (O=C-O-C). In the crystal, mol-ecules related by inversion symmetry are connected by weak C-H⋯O inter-actions into infinite chains. These inter-actions involve H atoms from a methyl group of the dimethyl residue and the O atoms of the ketone on one side of a mol-ecule; on the other side there are inter-actions between H atoms of the benzene ring and the carbonyl O atoms of the ester functionality. There are no directional inter-actions between the chains.
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