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Related Concept Videos

IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...
Hydrolysis of Chlorobenzene to Phenol: Dow Process01:10

Hydrolysis of Chlorobenzene to Phenol: Dow Process

Simple aryl halides do not react with nucleophiles under normal conditions. However, the reaction can proceed under drastic conditions involving high temperatures and high pressure to give the substituted products. For example, chlorobenzene is converted to phenol using aqueous sodium hydroxide at 350 °C under high pressure by the Dow process. The reaction follows an elimination-addition mechanism involving a benzyne intermediate. Here, the chloride ion is eliminated to generate the benzyne...
Nomenclature of Aromatic Compounds with a Single Substituent01:23

Nomenclature of Aromatic Compounds with a Single Substituent

Benzene is the simplest aromatic hydrocarbon or arene. The IUPAC names for simple monosubstituted benzene derivatives are derived by adding the substituent's name as a prefix to the parent benzene. For example, halobenzene, where the halogen could be fluoro (F), chloro (Cl), bromo (Br), and iodo (I).
Hydroboration-Oxidation of Alkenes03:08

Hydroboration-Oxidation of Alkenes

In addition to the oxymercuration–demercuration method, which converts the alkenes to alcohols with Markovnikov orientation, a complementary hydroboration-oxidation method yields the anti-Markovnikov product. The hydroboration reaction, discovered in 1959 by H.C. Brown, involves the addition of a B–H bond of borane to an alkene giving an organoborane intermediate. The oxidation of this intermediate with basic hydrogen peroxide forms an alcohol.
Reactions at the Benzylic Position: Oxidation and Reduction00:59

Reactions at the Benzylic Position: Oxidation and Reduction

The benzylic position describes the position of a carbon atom attached directly to a benzene ring. Benzene by itself does not undergo oxidation. In contrast, the benzylic carbon is quite reactive in the presence of strong oxidizing agents such as KMnO4 or H2CrO4. Therefore, alkylbenzenes are readily oxidized to benzoic acid, irrespective of the type of alkyl groups.
Reactions at the Benzylic Position: Halogenation01:11

Reactions at the Benzylic Position: Halogenation

Benzylic halogenation takes place under conditions that favor radical reactions such as heat, light, or a free radical initiator like peroxide.

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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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2-Propynyl 2-hydroxy-benzoate.

Stephan M Levonis, Milton J Kiefel, Todd A Houston

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary
    This summary is machine-generated.

    A novel compound, C(10)H(8)O(3), was synthesized as a potential antibacterial agent and building block for compound libraries. Its crystal structure reveals intramolecular hydrogen bonding, ensuring alkyne reactivity for further chemical synthesis.

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    Area of Science:

    • Organic Chemistry
    • Crystallography
    • Medicinal Chemistry

    Background:

    • Development of new antibacterial agents is crucial for combating drug resistance.
    • Synthesis of novel organic compounds serves as a foundation for creating diverse chemical libraries.
    • Understanding molecular structure and intermolecular interactions is key to designing functional molecules.

    Purpose of the Study:

    • To synthesize a new compound, C(10)H(8)O(3), for potential antibacterial applications.
    • To utilize the synthesized compound as a building block for creating compound libraries.
    • To elucidate the crystal structure and intermolecular interactions of the title compound.

    Main Methods:

    • Chemical synthesis of the title compound C(10)H(8)O(3).
    • Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.
    • Analysis of intra- and intermolecular interactions, including hydrogen bonding.

    Main Results:

    • The compound C(10)H(8)O(3) was successfully synthesized.
    • The crystal structure revealed two independent molecules in the asymmetric unit.
    • Intramolecular O-H⋯O hydrogen bonding confers rigidity, preserving alkyne group reactivity.
    • Intermolecular C-H⋯O interactions and hydrogen bonding form supramolecular chains along the b-axis.

    Conclusions:

    • The synthesized compound C(10)H(8)O(3) is a promising scaffold for developing new antibacterial agents.
    • The structural analysis confirms the compound's suitability as a building block for library synthesis due to its preserved reactivity.
    • The identified intermolecular interactions provide insights into crystal packing and potential solid-state properties.