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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-Meth-oxy-3-[(3,4,5-trimethoxy-anilino)methyl-idene]-3,4-dihydro-2H-1-benzopyran-4-one
Abstract:
The title mol-ecule, C(20)H(21)NO(6), adopts a keto-amine tautomeric form. An intra-molecular N-H⋯O hydrogen bond, classified as a resonanse-assisted hydrogen bond, influences the mol-ecular conformation; the two benzene rings form a dihedral angle of 24.6 (1)°. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds link mol-ecules into chains propagating along [001].
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