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Related Concept Videos

Nomenclature of Primary Amines01:17

Nomenclature of Primary Amines

Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
Nomenclature of Aryl and Heterocyclic Amines01:10

Nomenclature of Aryl and Heterocyclic Amines

The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview01:26

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview

Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.

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Updated: Jun 1, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

N-(Ferrocenylmethyl)-dodecan-1-amine.

Li-Zhen Sun1, Wei An, Hua-Cheng Zhang

  • 1School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|May 18, 2011
PubMed
Summary
This summary is machine-generated.

This study synthesized a novel iron complex, [Fe(C(5)H(5))(C(18)H(32)N)], via ferrocenecarbaldehyde amination. The resulting structure features nearly parallel cyclo-penta-dienyl rings and forms a 1D supramolecular network through C-H⋯π interactions.

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Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells
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Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

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Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
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Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection
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Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells
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Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Published on: December 13, 2016

Area of Science:

  • Organometallic Chemistry
  • Crystallography
  • Supramolecular Chemistry

Background:

  • Ferrocene derivatives are crucial in organometallic chemistry.
  • Amination reactions offer a pathway to functionalized ferrocenes.
  • Understanding intermolecular forces is key to designing advanced materials.

Purpose of the Study:

  • To synthesize and characterize a novel iron complex with a specific ligand.
  • To investigate the structural and crystallographic properties of the synthesized compound.
  • To explore the intermolecular interactions driving the self-assembly of the complex.

Main Methods:

  • Synthesis of the title compound via amination of ferrocenecarbaldehyde.
  • Single-crystal X-ray diffraction to determine the molecular and crystal structure.
  • Analysis of bond lengths, angles, and intermolecular interactions (C-H⋯π).

Main Results:

  • Successful synthesis of the iron complex [Fe(C(5)H(5))(C(18)H(32)N)].
  • The two cyclo-penta-dienyl (Cp) rings exhibit a small dihedral angle (1.36°).
  • A one-dimensional supramolecular structure is formed through weak C-H⋯π interactions.

Conclusions:

  • The amination of ferrocenecarbaldehyde yields a well-defined organometallic complex.
  • The crystal structure reveals a specific arrangement of Cp rings and intermolecular contacts.
  • Weak C-H⋯π interactions play a significant role in the self-assembly of this iron complex into a 1D structure.