Related Experiment Video
Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-[(2,6-Dichloro-benz-yl)amino]-N-(4-methyl-thia-zol-2-yl)acetamide
Abstract:
In the title compound, C(13)H(13)Cl(2)N(3)OS, the thia-zole and benzene rings are roughly parallel to one another in two layers [dihedral angle = 5.08 (2)°] because the N-C-C-N-C chain that links the two rings is folded [N-C-C-N torsion angle = 12.0 (2)°] rather than fully extended. An intra-molecular N-H⋯N inter-action occurs. In the crystal, weak inter-molecular N-H⋯N and C-H⋯O inter-actions are present and π-π inter-actions are indicated by the short distances [3.507 (3)-3.665 (2) Å] between the centroids of the thia-zole and benzene rings.
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