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Related Concept Videos

Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
Aldehydes and Ketones with Water: Hydrate Formation01:20

Aldehydes and Ketones with Water: Hydrate Formation

An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
Acid-Catalyzed Hydration of Alkenes02:45

Acid-Catalyzed Hydration of Alkenes

Alkenes react with water in the presence of an acid to form an alcohol. In the absence of acid, hydration of alkenes does not occur at a significant rate, and the acid is not consumed in the reaction. Therefore, alkene hydration is an acid-catalyzed reaction.
Oxymercuration-Reduction of Alkenes02:36

Oxymercuration-Reduction of Alkenes

Oxymercuration–reduction of alkenes is one of the major reactions converting alkenes to alcohols. It involves the hydration of alkenes with mercuric acetate in a mixture of tetrahydrofuran and water, forming an organomercury adduct. This is followed by a demercuration step in which the adduct is reduced to an alcohol using sodium borohydride.
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...

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Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
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Published on: January 10, 2025

Meranzin hydrate from Muraya paniculata.

Euis Julaeha, Unang Supratman, Mat Ropi Mukhtar

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study details the planar coumarin structure from Muraya paniculata. Its hydroxyl groups form hydrogen bonds, creating a unique sheet-like crystal arrangement.

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    Area of Science:

    • Natural Product Chemistry
    • Crystallography
    • Organic Chemistry

    Background:

    • Muraya paniculata is a plant known for its diverse phytochemical constituents.
    • Coumarins are a significant class of organic compounds with various biological activities.
    • Understanding the structural properties of isolated compounds is crucial for further research.

    Purpose of the Study:

    • To elucidate the crystal structure of a specific coumarin derivative isolated from Muraya paniculata.
    • To analyze the molecular geometry and intermolecular interactions of the title compound.
    • To characterize the solid-state packing and hydrogen bonding network.

    Main Methods:

    • Single crystal X-ray diffraction was employed to determine the crystal structure.
    • Analysis of the coumarin ring system's planarity using root-mean-square deviation.
    • Identification and analysis of hydrogen bonding interactions (O-H⋯O).

    Main Results:

    • The coumarin ring system of the compound C(15)H(18)O(5) was found to be planar, with an r.m.s. deviation of 0.017 Å.
    • Two hydroxyl groups within the molecule actively participate in intermolecular O-H⋯O hydrogen bonding.
    • These hydrogen bonds facilitate the formation of a sheet-like crystal structure.

    Conclusions:

    • The planar nature of the coumarin core is confirmed in the solid state.
    • Intermolecular hydrogen bonding plays a key role in the self-assembly of the compound into a sheet structure.
    • The structural insights provide a foundation for understanding the compound's properties and potential applications.