Related Experiment Video
Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
3,5-Dicarboxyanilinium nitrate dihydrate
1Ordered Matter Science Research Center, College of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China.
Abstract:
In the crystal of the title compound, C(8)H(8)NO(4) (+)·NO(3) (-)·2H(2)O, the 5-ammonio-isophthalic acid cations, the nitrate anions and the water mol-ecules are linked by N-H⋯O, O-H⋯O and C-H ⋯O hydrogen bonds into a three-dimensional network. The structure is further stabilized by aromatic π-π stacking inter-actions, with centroid-centroid separations of 3.827 (2) Å.
Related Concept Videos
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
Diazonium Group Substitution: –OH and –H
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Preparation of Nitriles
2° Amines to N-Nitrosamines: Reaction with NaNO2

