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Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-[(2-Chloro-7,8-dimethyl-quinolin-3-yl)meth-yl]pyridin-2(1H)-one
Abstract:
In the title compound, C(17)H(15)ClN(2)O, the quinoline ring system is nearly planar, with a maximum deviation from the mean plane of 0.074 (2) Å, and makes a dihedral angle of 81.03 (7)° with the pyridone ring. The crystal packing is stabilized by π-π stacking inter-actions between the pyridone and benzene rings of the quinoline ring system [centroid-centroid distance = 3.6754 (10) Å]. Furthermore, weak inter-molecular C-H⋯O hydrogen bonding links mol-ecules into supra-molecular chains along [001].
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