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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 2-acetamido-2-(1-acetyl-3-hydr-oxy-2-oxoindolin-3-yl)propanoate
Abstract:
In the title isatin compound, C(16)H(18)N(2)O(6), the pyrrolidine ring adopts an envelope conformation and is inclined at a dihedral angle of 7.31 (5)° with respect to the benzene ring. The acetyl group is disordered over two positions with refined occupancies of 0.503 (4) and 0.497 (4). These groups make dihedral angles of 12.6 (6) and 19.6 (7)° with the pyrrolidine ring. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link neighbouring mol-ecules into infinite chains along the b axis. These chains are further inter-connected by inter-molecular O-H⋯O hydrogen bonds into two-dimensional arrays parallel to the bc plane. Weak inter-molecular C-H⋯π inter-actions further stabilize the crystal structure.
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