N'-(2-Hydr-oxy-4-methoxy-benzyl-idene)isonicotinohydrazide
1Modern Medical Research Center, Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China.
Summary
Researchers synthesized a novel organic compound, C(14)H(13)N(3)O(3), via a condensation reaction. The study details its molecular structure, including a trans configuration and specific dihedral angle, and its crystal packing via hydrogen bonding.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Schiff bases are versatile organic compounds with diverse applications.
- Understanding the structure-property relationships of novel Schiff bases is crucial for materials science.
Purpose of the Study:
- To synthesize and characterize a new Schiff base compound derived from 2-hydroxy-4-methoxy-benzaldehyde and isonicotinohydrazide.
- To elucidate the molecular structure and crystal packing of the synthesized compound.
Main Methods:
- Condensation reaction in methanol solution.
- Single-crystal X-ray diffraction analysis.
- Analysis of intermolecular and intramolecular hydrogen bonding interactions.
Main Results:
- The compound C(14)H(13)N(3)O(3) was successfully synthesized.
- The molecular structure exhibits a trans configuration around the C=N and C-N bonds.
- The dihedral angle between the benzene and pyridine rings is 27.3(2)°.
- Crystal structure reveals zigzag chains formed by N-H⋯N intermolecular hydrogen bonds (graph set C(7)).
- An intramolecular O-H⋯N hydrogen bond was identified.
Conclusions:
- The synthesis yielded a novel Schiff base with a defined molecular geometry.
- The crystal structure is stabilized by a combination of intermolecular and intramolecular hydrogen bonding.
- The findings contribute to the understanding of Schiff base structures and their solid-state arrangements.
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