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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-[3-(Bromo-meth-yl)benz-yloxy]-3-methoxy-benzaldehyde
Abstract:
In the title compound, C(16)H(15)BrO(3), the dihedral angle between the mean planes of the two benzene rings is 76.64 (2)°. In the crystal structure, there are weak π-π stacking inter-actions, with a centroid-centroid distance of 3.724 (3) Å, as well as an inter-molecular C⋯Br distance [3.495 (2) Å] which is slightly less than the sum of the van der Waals radii for these atoms.
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For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...

