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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
1-(4-Nitro-benzo-yl)-3-(4-nitro-phen-yl)-thio-urea acetone hemisolvate
Liang Xian1, Lujuan Cui, Ming Cheng
1Chemical Engineering Institute, Northwest University for Nationalities, Lanzhou 730124, People's Republic of China.
Abstract:
In the title compound, C(14)H(10)N(4)O(5)S·0.5C(3)H(6)O, the nitro-benzoyl and nitro-phenyl groups have trans and cis configurations, respectively, with respect to the thio-urea S atom. The mol-ecular conformation is stabilized by intra-molecular N-H⋯O and C-H⋯S hydrogen bonds. The acetone solvent mol-ecule possesses a crystallographically imposed twofold axis. In the crystal packing, thio-urea mol-ecules are linked by inter-molecular C-H⋯O hydrogen-bond inter-actions to form chains running parallel to the c axis. The chains are further bridged via N-H⋯O and C-H⋯O hydrogen bonds involving the acetone mol-ecules.
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