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Updated: Jun 1, 2026
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Chemical Triphosphorylation of Oligonucleotides
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5-Bromo-5-bromo-methyl-2-phen-oxy-1,3,2-dioxaphospho-rinan-2-one
Summary
This study details the chair conformation of a 1,3,2-dioxaphosphorinane derivative. Molecular interactions in crystal packing reveal C-H⋯O, C-H⋯Br, and C-H⋯π linkages forming sheet-like structures.
Area of Science:
- Organophosphorus Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- 1,3,2-dioxaphosphorinane derivatives are important in organic synthesis and medicinal chemistry.
- Understanding the conformational preferences and intermolecular interactions of these compounds is crucial for predicting their properties and reactivity.
Purpose of the Study:
- To elucidate the three-dimensional structure and conformational analysis of a specific 1,3,2-dioxaphosphorinane derivative.
- To investigate the intermolecular interactions governing the crystal packing of this organophosphorus compound.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular structure and crystal packing.
- Conformational analysis was performed based on the determined crystal structure.
Main Results:
- The 1,3,2-dioxaphosphorinane ring adopts a chair conformation with specific equatorial and axial orientations of substituents (P=O, phenoxy, bromo, bromo-methyl).
- Crystal packing is characterized by intermolecular interactions including C-H⋯O, C-H⋯Br, and C-H⋯π, leading to the formation of chains, sheets, and anti-parallel arrangements.
Conclusions:
- The study provides detailed structural insights into a 1,3,2-dioxaphosphorinane derivative, highlighting its conformational preferences.
- The identified intermolecular interactions are key to understanding the solid-state architecture and potential supramolecular assembly of this class of compounds.
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