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Updated: Jun 1, 2026
06:46
Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
(E)-3-(3-Bromo-phen-yl)-1-(4-methyl-phenyl)prop-2-en-1-one
Summary
Researchers synthesized a novel brominated organic compound, C(16)H(13)BrO, using a base-catalyzed reaction. The study details its E-configured propenone unit, aromatic ring orientation, and crystal structure stabilized by bromine interactions.
Area of Science:
- Organic Chemistry
- Crystallography
- Materials Science
Background:
- Chalcones and their derivatives are important organic compounds with diverse applications.
- Understanding the structure-property relationships of novel chalcone derivatives is crucial for developing new materials.
Purpose of the Study:
- To synthesize and characterize a novel brominated chalcone derivative.
- To elucidate the molecular structure and crystal packing of the synthesized compound.
Main Methods:
- Synthesis via Claisen-Schmidt condensation of 3-bromo-benzaldehyde and 4-methyl-acetophenone using potassium hydroxide (KOH).
- Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.
Main Results:
- The compound C(16)H(13)BrO was successfully synthesized.
- The molecule exhibits an E configuration around the C=C double bond.
- The crystal structure is characterized by a dihedral angle of 46.91° between aromatic rings and stabilized by intermolecular Br⋯Br interactions (3.4549 Å).
Conclusions:
- The study successfully synthesized and characterized a new brominated chalcone.
- The crystal structure reveals specific intermolecular interactions that influence solid-state packing.
- This work contributes to the understanding of structure-property relationships in brominated organic compounds.
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