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Updated: Jun 1, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
r-2,c-6-Bis(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one
Abstract:
The asymmetric unit of the title compound, C(21)H(25)NO(3), contains two crystallographically independent mol-ecules (A and B). In both mol-ecules, the piperidine ring adopts a chair conformation, with the methoxy-phenyl rings attached equatorially. The dihedral angle between the two benzene rings in mol-ecule A is 73.79 (8)°; the corresponding value in mol-ecule B is 77.71 (8)°. The mol-ecules are linked by N-H⋯O hydrogen bonds. In addition, C-H⋯π inter-actions are also found in the crystal structure.
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