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Updated: Jun 1, 2026
14:18
A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
3-(4-Methoxy-phen-yl)pent-2-ene-1,5-dioic acid.
Summary
Molecules in the title compound self-assemble into anti-parallel sheets using hydrogen bonds. These sheets form chains, creating a specific superstructure, demonstrating crystal engineering principles.
Area of Science:
- Crystal engineering
- Supramolecular chemistry
- Organic chemistry
Background:
- Hydrogen bonding is a key interaction in crystal engineering.
- Understanding molecular self-assembly is crucial for designing new materials.
- The R(2)(2)(8) motif is a common hydrogen-bonding pattern.
Purpose of the Study:
- To investigate the crystal structure and hydrogen bonding of the title compound C(12)H(12)O(5).
- To analyze the formation of supramolecular assemblies from molecular building blocks.
Main Methods:
- Single-crystal X-ray diffraction was used to determine the molecular structure.
- Analysis of hydrogen bonding interactions (O-H⋯O) was performed.
- Supramolecular structure was characterized using crystallographic data.
Main Results:
- The title compound, C(12)H(12)O(5), forms anti-parallel hydrogen-bonded sheets.
- Inversion dimers generated via two O-H⋯O hydrogen bonds link molecules.
- The R(2)(2)(8) motif acts as a building block for a C(2)(2)(8) superstructure.
Conclusions:
- The study elucidates the self-assembly mechanism of C(12)H(12)O(5) through hydrogen bonding.
- The formation of sheets and chains highlights the role of specific motifs in crystal engineering.
- This work contributes to the understanding of supramolecular architecture in organic compounds.
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