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Updated: Jun 1, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-(3-Phenyl-isoquinolin-1-yl)hydrazine.
Summary
This study details the crystal structure of a C(15)H(13)N(3) compound, revealing two unique molecules within its asymmetric unit. Molecular dimers stabilize the crystal packing through hydrogen bonding interactions.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Understanding molecular arrangements in crystalline solids is crucial for materials science.
- The specific compound C(15)H(13)N(3) presents an interesting case for structural analysis.
- Previous studies may not have fully elucidated the crystallographic details of this molecule.
Purpose of the Study:
- To determine and describe the crystal structure of the title compound, C(15)H(13)N(3).
- To analyze the spatial arrangement and interactions of the independent molecules within the crystal lattice.
- To investigate the intermolecular forces governing crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to obtain detailed structural data.
- The crystallographic data was analyzed to identify independent molecules and their orientations.
- Intermolecular interactions, such as hydrogen bonding, were examined to understand crystal stabilization.
Main Results:
- The asymmetric unit contains two independent molecules of C(15)H(13)N(3).
- Distinct dihedral angles were measured between the isoquinoline and phenyl rings in each molecule (4.38(2)° and 10.14(3)°).
- Crystal packing is significantly influenced by N-H⋯N hydrogen-bonded molecular dimers formed across a center of symmetry.
Conclusions:
- The crystal structure of C(15)H(13)N(3) is characterized by the presence of two independent molecules.
- The observed dihedral angles provide insights into the conformational preferences of the compound.
- Hydrogen-bonded dimers are key to the observed crystal packing, highlighting the role of intermolecular forces in solid-state structure.
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