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Updated: Jun 1, 2026
05:07
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
3,5-Dichloro-6-methyl-pyridin-2-amine.
Summary
This study details the crystal structure of a novel compound, C(6)H(6)Cl(2)N(2). It reveals specific hydrogen bonding interactions that lead to the formation of unique molecular arrangements and crystal packing in solid-state chemistry.
Area of Science:
- Crystal engineering and supramolecular chemistry.
- Solid-state chemistry and molecular structure analysis.
Background:
- Understanding intermolecular forces is crucial for designing materials with specific properties.
- Hydrogen bonding plays a significant role in the self-assembly of molecules in crystals.
Purpose of the Study:
- To elucidate the crystal structure of the compound C(6)H(6)Cl(2)N(2).
- To investigate the types and roles of intra- and inter-molecular interactions in its solid-state arrangement.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of non-covalent interactions, including hydrogen bonds (N-H⋯Cl, C-H⋯Cl, N-H⋯N), was performed.
Main Results:
- Intra-molecular hydrogen bonds (N-H⋯Cl, C-H⋯Cl) form five-membered rings (S(5) motifs).
- Inter-molecular hydrogen bonds (N-H⋯N) create dimeric units with R(2)(2)(8) ring motifs.
- These dimers are further linked by N-H⋯Cl interactions, leading to columnar packing in the crystal.
Conclusions:
- The crystal structure is governed by a combination of intra- and inter-molecular hydrogen bonding.
- Specific hydrogen bonding patterns dictate the formation of dimers and their subsequent arrangement into columns.
- This detailed structural analysis provides insights into the principles of crystal engineering for this class of compounds.
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