Related Experiment Video
Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Butyl 2-(5-iodo-3-methyl-sulfinyl-1-benzofuran-2-yl)acetate
Abstract:
In the title compound, C(15)H(17)IO(4)S, the O atom and the methyl group of the methyl-sulfinyl substituent lie on opposite sides of the plane of the benzofuran fragment. The crystal structure is stabilized by weak inter-molecular C-H⋯π inter-actions between a methyl H atom of the methyl-sulfinyl group and the benzene ring of the benzofuran system, and by an I⋯O halogen bond of 3.173 (3) Å and a nearly linear C-I⋯O angle of 171.7 (1)°. In addition, the crystal structure exhibits weak inter-molecular C-H⋯O hydrogen bonds. The O atom of the carbonyl group and the butyl chain are both disordered over two positions with site-occupancy factors from refinement of 0.55 (4) and 0.45 (4) (for the O atom), and 0.76 (2) and 0.24 (2) (for the butyl group).
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Electrophilic Aromatic Substitution: Friedel–Crafts Acylation of Benzene
Nomenclature of Aromatic Compounds with a Single Substituent
IUPAC Nomenclature of Aldehydes
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis

![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)