Related Experiment Video
Updated: Jun 1, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
2,2'-(1-Phenyl-1H-pyrazole-3,5-di-yl)diphenol
Abstract:
The title compound, C(21)H(16)N(2)O(2), was derived from 1-(2-hydroxy-phen-yl)-3-(-methoxy-phen-yl)propane-1,3-dione. The mol-ecular structure of the title compound is stabilized by an intra-molecular O-H⋯N hydrogen bond. The dihedral angle between the hydroxy-phenyl ring involved in this intra-molecular hydrogen bond and the pyrazole ring is significantly smaller [10.07 (6)°] than the dihedral angle between the pyrazole and the other hydroxy-phenyl ring [36.64 (5)°]. The benzene ring makes a dihedral angle of 54.95 (3)° with the pyrazole ring. The crystal packing is stabilized by O-H⋯O and O-H⋯N hydrogen bonds.
Related Concept Videos
Structure and Nomenclature of Alcohols and Phenols
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
Hydrolysis of Chlorobenzene to Phenol: Dow Process
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Acidity and Basicity of Alcohols and Phenols
Benzene to Phenol via Cumene: Hock Process
Preparation of Diols and Pinacol Rearrangement
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.

