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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N,N'-Diacetyl-N'-[(4-nitro-phen-oxy)acetyl]acetohydrazide.
This study reveals that two molecules of C(14)H(15)N(3)O(7) form a dimer through pi-pi interactions. Hydrogen bonds further stabilize the crystal structure, offering insights into molecular assembly.
Area of Science:
- Crystallography
- Supramolecular Chemistry
Background:
- Understanding molecular interactions is crucial for materials science.
- Crystal packing influences material properties.
Purpose of the Study:
- To elucidate the crystal structure and intermolecular interactions of C(14)H(15)N(3)O(7).
- To investigate the role of pi-pi interactions and hydrogen bonding in crystal stabilization.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- Intermolecular distances and bonding patterns were analyzed.
Main Results:
- The asymmetric unit contains two independent molecules forming a pseudocentrosymmetric dimer.
- A short pi-pi interaction (3.722 Å) was observed between benzene rings.
- Extensive C-H⋯O hydrogen bonds contribute to crystal packing.
Conclusions:
- The crystal structure is stabilized by a combination of pi-pi interactions and hydrogen bonding.
- These findings provide a basis for understanding the self-assembly of this compound.
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