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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-[(2-Hydr-oxy-2,2-diphenyl-ethyl)(meth-yl)amino]-N,N-dimethyl-ethanaminium bromide
Viktoria H Gessner1, Christian Däschlein, Carsten Strohmann
1Anorganische Chemie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Abstract:
The title compound, C(19)H(27)N(2)O(+)·Br(-), is the hydro-bromide of the trapping product of lithia-ted N,N,N',N'-tetramethylethylenediamine (TMEDA) with benzophenone. Thereby, the N atom of the NMe(2) group is selectively protonated and the respective trapping product represents a potential tridentate ligand with one O and two N donor atoms. The H atoms at N (H2N) and O (H1O) are involved in hydrogen bonds with the Br(-). The mol-ecular structure shows all donor atoms to be arranged on one side of the mol-ecule, thus indicating a potential threefold coordination of a Lewis acid.
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