![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
1,3-Dimethyl-2,6-diphenyl-piperidin-4-one
Summary
This study details the molecular structure of C(19)H(21)NO, revealing a chair conformation with equatorial orientations for its substituents. The crystal structure analysis identified centrosymmetric dimers linked by weak hydrogen bonds.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure Analysis
Background:
- Understanding the three-dimensional structure of organic molecules is crucial for predicting their properties and reactivity.
- Piperidone derivatives are important scaffolds in medicinal chemistry.
Purpose of the Study:
- To elucidate the precise molecular conformation and crystal packing of the title compound, C(19)H(21)NO.
- To investigate intermolecular interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Conformational analysis of the piperidone ring and substituent orientations was performed.
Main Results:
- The 4-piperidone ring adopts a chair conformation.
- The two benzene rings and the methyl group exhibit equatorial orientations.
- Centrosymmetric dimers are formed via weak intermolecular C-H⋯O hydrogen bonds.
- The dihedral angle between the aromatic rings is 58.51(5)°.
Conclusions:
- The determined conformation and crystal packing provide fundamental insights into the solid-state behavior of this molecule.
- The identified hydrogen bonding pattern influences the supramolecular assembly.
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![[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2Ffiles%2Fmedia%2Fscience-education%2Fscience-education-thumbs%2F12417.jpg&w=3840&q=75)
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