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Updated: Jun 1, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
4-(4-Methoxy-phen-yl)piperazin-1-ium chloride
This study details the crystal structure of a piperazine derivative, revealing a specific dihedral angle between its benzene and piperazine rings. The arrangement is stabilized by intermolecular hydrogen bonds and pi-stacking interactions.
Area of Science:
- Crystallography
- Organic Chemistry
- Supramolecular Chemistry
Background:
- Piperazine derivatives are important in medicinal chemistry.
- Understanding molecular packing is crucial for material properties.
Purpose of the Study:
- To characterize the crystal structure of a novel piperazine derivative.
- To investigate intermolecular interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed.
- Analysis of bond lengths, angles, and intermolecular contacts.
Main Results:
- The dihedral angle between the benzene and piperazine rings is 39.20(8)°.
- Intermolecular N-H⋯Cl hydrogen bonds were identified.
- C-H⋯π interactions between benzene rings were observed.
Conclusions:
- The crystal structure provides insights into the conformational preferences of the piperazine ring.
- Hydrogen bonding and C-H⋯π interactions play a significant role in stabilizing the crystal packing.
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